The Brilliant James Madison
http://www.nationalreview.com/articles/294484/madison-s-last-stand-rich-lowry
The words of Madison from the Federalist Papers:
“The powers delegated by the proposed Constitution to the federal government are few and defined. Those which are to remain in the State governments are numerous and indefinite.”
Madison thought this division of power so important for a reason:
“In the compound republic of America, the power surrendered by the people is first divided between two distinct governments, and then the portion allotted to each subdivided among distinct and separate departments. Hence a double security arises to the rights of the people. The different governments will control each other, at the same time that each will be controlled by itself.”
Publius Prime 
“In the mind of contemporary progressivism…”
Republicans are just as willing to shred the Constitution in pursuit of their ideological preferences as leftists are. Just substitute “war on drugs” for “healthcare reform.”
Or did Madison envision federal agents conducting military-style raids to prevent citizens from possessing and/or consuming certain substances?